Question
A 59 year old male is given is given an antibiotic orally 2 mg/Kg BW (Weight 60 Kg). Blood samples were withdrawn periodically and plasma level of antibiotics were determined using HPLC assay. Assuming drug absorption is rapid and complete and that the drug follows first order kinetics, draw a plasma drug concentration (de) vs time curve and calculate a. Elimination rate constant and b. elimination half life Time 0.25 Pde (yg/ml) 2.2 3.8 0.5 0.75 1.0 1.5 5.8 6.8 7.1 7.1 3.0 6.9 4.0 6.1 4.8 3.5 1.9 0.3
Answer
elimination rate constant (-k) = slope =.115 /sec
Half life period= 0.693× k= 0.693×.115 = 0.079
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